Version 5.4
Mus musculus Gene: Eif2b2
Summary
InnateDB Gene IDBG-158157.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif2b2
Gene Name eukaryotic translation initiation factor 2B, subunit 2 beta
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000004788
Encoded Proteins
IDBP-158159
eukaryotic translation initiation factor 2B, subunit 2 beta
IDBP-536985
eukaryotic translation initiation factor 2B, subunit 2 beta
IDBP-536620
eukaryotic translation initiation factor 2B, subunit 2 beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119718:
This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:85219481-85226628
Strand Forward strand
Band D1
Transcripts
ENSMUST00000004910 ENSMUSP00000004910
ENSMUST00000140900 ENSMUSP00000122954
ENSMUST00000136495 ENSMUSP00000122720
ENSMUST00000150935
ENSMUST00000151925
ENSMUST00000128709
ENSMUST00000130760
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
Biological Process
GO:0001541 ovarian follicle development
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0007417 central nervous system development
GO:0014003 oligodendrocyte development
GO:0042552 myelination
GO:0043087 regulation of GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0044237 cellular metabolic process
GO:0051716 cellular response to stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005851 eukaryotic translation initiation factor 2B complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000119718
View Gene Order
ENSBTAG00000008664
Not yet available
Pathways
NETPATH
REACTOME
REACT_254308
Translation pathway
REACT_247926
Metabolism of proteins pathway
REACT_229570
Cap-dependent Translation Initiation pathway
REACT_262064
Eukaryotic Translation Initiation pathway
REACT_233572
Gene Expression pathway
REACT_229709
Recycling of eIF2:GDP pathway
KEGG
mmu03013
RNA transport pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1815
Recycling of eIF2:GDP pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_71
Gene Expression pathway
REACT_226022
Gene Expression pathway
REACT_218564
Eukaryotic Translation Initiation pathway
REACT_225918
Cap-dependent Translation Initiation pathway
REACT_209048
Translation pathway
REACT_206472
Recycling of eIF2:GDP pathway
REACT_213782
Metabolism of proteins pathway
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D3Z7J6
UniProt Splice Variant
Entrez Gene 217715
UniGene Mm.29041
RefSeq NM_145445 XM_006515702
OMIM
CCDS CCDS26053
HPRD
IMGT
MGI ID MGI:2145118
MGI Symbol Eif2b2
EMBL AC159237
GenPept
RNA Seq Atlas 217715

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca