Version 5.4
Mus musculus Gene: Dok7
Summary
InnateDB Gene IDBG-156612.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dok7
Gene Name docking protein 7
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000044716
Encoded Proteins
IDBP-156614
docking protein 7
IDBP-156616
docking protein 7
IDBP-252125
docking protein 7
IDBP-541570
docking protein 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175920:
The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:35056813-35087839
Strand Forward strand
Band B2
Transcripts
ENSMUST00000101298 ENSMUSP00000098856
ENSMUST00000050709 ENSMUSP00000059538
ENSMUST00000114270 ENSMUSP00000109909
ENSMUST00000133381 ENSMUSP00000116023
ENSMUST00000155097
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005158 insulin receptor binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0007528 neuromuscular junction development
GO:0043113 receptor clustering
GO:0061098 positive regulation of protein tyrosine kinase activity
Cellular Component
GO:0005886 plasma membrane
GO:0030054 cell junction
GO:0031594 neuromuscular junction
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000175920
View Gene Order
ENSBTAG00000009742
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.205483
RefSeq NM_172708 XM_006503898 XM_006503899 XM_006503900 XM_006503901
OMIM
CCDS CCDS19224
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca