Homo sapiens Gene: SEL1L | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-14682.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | SEL1L | ||||||||||||||||||
Gene Name | sel-1 suppressor of lin-12-like (C. elegans) | ||||||||||||||||||
Synonyms | PRO1063; SEL1-LIKE; SEL1L1 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000071537 | ||||||||||||||||||
Encoded Proteins |
sel-1 suppressor of lin-12-like (C. elegans)
sel-1 suppressor of lin-12-like (C. elegans)
sel-1 suppressor of lin-12-like (C. elegans)
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 14:81471549-81533861 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | q31.1 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Pre-NOTCH Processing in Golgi pathway
Processing-defective Hh variants abrogate ligand secretion pathway
Signaling by Hedgehog pathway
Pre-NOTCH Expression and Processing pathway
Signal Transduction pathway
Hh ligand biogenesis disease pathway
Hedgehog ligand biogenesis pathway
Signaling by NOTCH pathway
Disease pathway
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KEGG |
Protein processing in endoplasmic reticulum pathway
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INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q9UBV2 | ||||||||||||||||||
TrEMBL | G3V3B3 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 6400 | ||||||||||||||||||
UniGene | Hs.181300 Hs.708488 Hs.708669 | ||||||||||||||||||
RefSeq | NM_001244984 NM_005065 XM_005267988 | ||||||||||||||||||
HUGO | HGNC:10717 | ||||||||||||||||||
OMIM | 602329 | ||||||||||||||||||
CCDS | CCDS58333 CCDS9876 | ||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AB020335 AB024763 AF052059 AF157516 AF198631 AF198632 AF198633 AF198634 AF198635 AF198636 AF198637 AF198638 AF198639 AF198640 AF198641 AF198642 AF198643 AF198644 AF198645 AF198646 AF198647 AL121769 AL136039 AY358651 | ||||||||||||||||||
GenPept | AAF24176 AAF29413 AAL40905 AAQ89014 BAA87904 BAA89204 | ||||||||||||||||||
RNA Seq Atlas | 6400 | ||||||||||||||||||