InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Zap70

Summary

InnateDB Gene

IDBG-145089.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zap70

Gene Name

zeta-chain (TCR) associated protein kinase

Synonyms

mrtle; mur; Srk; ZAP-70

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026117

Encoded Proteins

IDBP-145091

zeta-chain (TCR) associated protein kinase

IDBP-789041

zeta-chain (TCR) associated protein kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the protein tyrosine kinase family. The encoded protein is essential for development of T lymphocytes and thymocytes, and functions in the initial step of T lymphocyte receptor-mediated signal transduction. A mutation in this gene causes chronic autoimmune arthritis, similar to rheumatoid arthritis in humans. Mice lacking this gene are deficient in alpha-beta T lymphocytes in the thymus. In humans, mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T lymphocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:36761798-36782816

Strand

Forward strand

Band

Transcripts

ENSMUST00000027291	ENSMUSP00000027291
ENSMUST00000185871	ENSMUSP00000139990
ENSMUST00000186624
ENSMUST00000190128

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	53 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001784	phosphotyrosine binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006955	immune response
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0035556	intracellular signal transduction
GO:0043366	beta selection
GO:0045059	positive thymic T cell selection
GO:0045060	negative thymic T cell selection
GO:0045061	thymic T cell selection
GO:0045582	positive regulation of T cell differentiation
GO:0046638	positive regulation of alpha-beta T cell differentiation
GO:0046641	positive regulation of alpha-beta T cell proliferation
GO:0046777	protein autophosphorylation
GO:0050850	positive regulation of calcium-mediated signaling
GO:0050852	T cell receptor signaling pathway

Cellular Component

GO:0001772	immunological synapse
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0042101	T cell receptor complex
GO:0045121	membrane raft