Version 5.4
Homo sapiens Gene: ACR
Summary
InnateDB Gene IDBG-14292.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACR
Gene Name acrosin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000100312
Encoded Proteins
IDBP-14294
acrosin
IDBP-584959
acrosin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:50738196-50745334
Strand Forward strand
Band q13.33
Transcripts
ENST00000216139 ENSP00000216139
ENST00000533930
ENST00000529621 ENSP00000435120
ENST00000527761
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004040 amidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0005537 mannose binding
GO:0008144 drug binding
GO:0008233 peptidase activity
GO:0008270 zinc ion binding
GO:0042806 fucose binding
Biological Process
GO:0002077 acrosome matrix dispersal
GO:0006508 proteolysis
GO:0007190 activation of adenylate cyclase activity
GO:0007338 single fertilization
GO:0007339 binding of sperm to zona pellucida
GO:0007340 acrosome reaction
GO:0007341 penetration of zona pellucida
GO:0032504 multicellular organism reproduction
GO:0048545 response to steroid hormone
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005798 Golgi-associated vesicle
GO:0043159 acrosomal matrix
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022622
View Gene Order
ENSBTAG00000010182
Not yet available
Pathways
NETPATH
REACTOME
REACT_163938
Acrosome Reaction pathway
REACT_163914
Fertilization pathway
REACT_163848
Reproduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.370870
RefSeq NM_001097
HUGO
OMIM
CCDS CCDS14101
HPRD 06342
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca