InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BNIP3L

Summary

InnateDB Gene

IDBG-13074.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BNIP3L

Gene Name

BCL2/adenovirus E1B 19kDa interacting protein 3-like

Synonyms

BNIP3a; NIX

Species

Homo sapiens

Ensembl Gene

ENSG00000104765

Encoded Proteins

IDBP-13078

BCL2/adenovirus E1B 19kDa interacting protein 3-like

IDBP-478468

BCL2/adenovirus E1B 19kDa interacting protein 3-like

IDBP-479098

BCL2/adenovirus E1B 19kDa interacting protein 3-like

IDBP-477345

BCL2/adenovirus E1B 19kDa interacting protein 3-like

IDBP-473962

BCL2/adenovirus E1B 19kDa interacting protein 3-like

IDBP-476607

BCL2/adenovirus E1B 19kDa interacting protein 3-like

IDBP-813082

BCL2/adenovirus E1B 19kDa interacting protein 3-like

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 26253785

[Mus musculus] Mitophagy-inducing proteins Bnip3 and Bnip3l play a regulatory role in the generation of robust natural killer cell memory.

Entrez Gene

Summary

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. This protein counteracts the apoptotic inducer BNIP3 and may play a role in tumor suppression. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:26382898-26505636

Strand

Forward strand

Band

p21.2

Transcripts

ENST00000380629	ENSP00000370003
ENST00000520077	ENSP00000428919
ENST00000523949	ENSP00000429171
ENST00000523515	ENSP00000429698
ENST00000520409	ENSP00000428597
ENST00000518611	ENSP00000429851
ENST00000521254
ENST00000620910	ENSP00000479522

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.

Experimentally validated
Total	44 [view]
Protein-Protein	41 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005521	lamin binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0016032	viral process
GO:0035694	mitochondrial protein catabolic process
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0051607	defense response to virus
GO:0097345	mitochondrial outer membrane permeabilization

Cellular Component

GO:0005635	nuclear envelope
GO:0005739	mitochondrion
GO:0005740	mitochondrial envelope
GO:0005741	mitochondrial outer membrane
GO:0005783	endoplasmic reticulum
GO:0016021	integral component of membrane
GO:0031224	intrinsic component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022051

View Gene Order

ENSBTAG00000021307

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

p53downstreampathway

Direct p53 effectors

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.718221

RefSeq

NM_004331 XM_005273617

HUGO

OMIM

CCDS

CCDS6050

HPRD

07288

IMGT

EMBL

GenPept

RNA Seq Atlas