Version 5.4
Homo sapiens Gene: RBBP6
Summary
InnateDB Gene IDBG-21023.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBBP6
Gene Name retinoblastoma binding protein 6
Synonyms MY038; P2P-R; PACT; RBQ-1; SNAMA
Species Homo sapiens
Ensembl Gene ENSG00000122257
Encoded Proteins
IDBP-21025
retinoblastoma binding protein 6
IDBP-21027
retinoblastoma binding protein 6
IDBP-21031
retinoblastoma binding protein 6
IDBP-373016
retinoblastoma binding protein 6
IDBP-753485
IDBP-749408
IDBP-807457
retinoblastoma binding protein 6
IDBP-754594
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:24537693-24572863
Strand Forward strand
Band p12.1
Transcripts
ENST00000381039 ENSP00000370427
ENST00000319715 ENSP00000317872
ENST00000348022 ENSP00000316291
ENST00000452655 ENSP00000390537
ENST00000568015 ENSP00000460821
ENST00000564726
ENST00000567686 ENSP00000457716
ENST00000562430
ENST00000562683 ENSP00000481477
ENST00000564314 ENSP00000456750
ENST00000570185
ENST00000568316
ENST00000613729
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
Experimentally validated
Total 54 [view]
Protein-Protein 54 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001701 in utero embryonic development
GO:0016567 protein ubiquitination
GO:0035264 multicellular organism growth
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0048568 embryonic organ development
GO:0061053 somite development
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030779
View Gene Order
ENSBTAG00000009441
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.188553 Hs.614143
RefSeq NM_006910 NM_018703 NM_032626
HUGO
OMIM
CCDS CCDS10621 CCDS10622 CCDS45444
HPRD 02964
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca