InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RBBP6

Summary

InnateDB Protein

IDBP-373016.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RBBP6

Protein Name

retinoblastoma binding protein 6

Synonyms

MY038; P2P-R; PACT; RBQ-1; SNAMA;

Species

Homo sapiens

Ensembl Protein

ENSP00000390537

InnateDB Gene

IDBG-21023 (RBBP6)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth.

Subcellular Localization

Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with mitotic chromosomes. Colocalizes with NEK6 in the centrosome.

Disease Associations

Tissue Specificity

Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer. {ECO:0000269PubMed:15475430}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.

Experimentally validated
Total	54 [view]
Protein-Protein	54 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0044822	poly(A) RNA binding