Version 5.4
Homo sapiens Gene: TSEN2
Summary
InnateDB Gene IDBG-19103.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSEN2
Gene Name tRNA splicing endonuclease 2 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000154743
Encoded Proteins
IDBP-19107
tRNA splicing endonuclease 2 homolog (S. cerevisiae)
IDBP-292702
tRNA splicing endonuclease 2 homolog (S. cerevisiae)
IDBP-364302
tRNA splicing endonuclease 2 homolog (S. cerevisiae)
IDBP-364304
tRNA splicing endonuclease 2 homolog (S. cerevisiae)
IDBP-364310
tRNA splicing endonuclease 2 homolog (S. cerevisiae)
IDBP-364311
tRNA splicing endonuclease 2 homolog (S. cerevisiae)
IDBP-364312
tRNA splicing endonuclease 2 homolog (S. cerevisiae)
IDBP-364315
tRNA splicing endonuclease 2 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:12484432-12539623
Strand Forward strand
Band p25.2
Transcripts
ENST00000284995 ENSP00000284995
ENST00000402228 ENSP00000385976
ENST00000454502 ENSP00000392029
ENST00000446004 ENSP00000406238
ENST00000444864 ENSP00000407974
ENST00000415684 ENSP00000416510
ENST00000455118 ENSP00000408744
ENST00000412698 ENSP00000408528
ENST00000473755
ENST00000490981
ENST00000475595
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000213 tRNA-intron endonuclease activity
GO:0003676 nucleic acid binding
GO:0016829 lyase activity
Biological Process
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation
GO:0006397 mRNA processing
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0000214 tRNA-intron endonuclease complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042389
View Gene Order
ENSBTAG00000037980
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.335550 Hs.629514
RefSeq NM_001145392 NM_001145393 NM_001145394 NM_001145395 NM_025265 XM_005265495 XM_005265497 XM_005265499
HUGO
OMIM
CCDS CCDS2611 CCDS46757 CCDS46758 CCDS46759
HPRD 10576
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca