Version 5.4
Homo sapiens Protein: TSEN2
Summary
InnateDB Protein IDBP-364302.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSEN2
Protein Name tRNA splicing endonuclease 2 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000392029
InnateDB Gene IDBG-19103 (TSEN2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000213 tRNA-intron endonuclease activity
GO:0003676 nucleic acid binding
GO:0016829 lyase activity
Biological Process
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation
GO:0006397 mRNA processing
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0000214 tRNA-intron endonuclease complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
Protein Structure and Domains
PDB ID
InterPro IPR006677 tRNA intron endonuclease, catalytic domain-like
IPR006678 tRNA intron endonuclease, N-terminal
IPR016589 tRNA-splicing endonuclease, SEN2 subunit
PFAM PF01974
PF02778
PRINTS
PIRSF PIRSF011789
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NCE0
PhosphoSite PhosphoSite-Q8NCE0
TrEMBL
UniProt Splice Variant
Entrez Gene 80746
UniGene Hs.629514
RefSeq NP_001138866
HUGO HGNC:28422
OMIM 608753
CCDS CCDS46758
HPRD 10576
IMGT
EMBL AC018500 AC090947 AK074794 AK225875 AK300449 BC004178 BC004211 BC019582 BC021975 CH471055
GenPept AAH04178 AAH04211 AAH19582 AAH21975 BAC11213 BAH13287 EAW64129

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca