Version 5.4
Bos taurus Gene: TSEN2
Summary
InnateDB Gene IDBG-646389.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSEN2
Gene Name tRNA-splicing endonuclease subunit Sen2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000037980
Encoded Proteins
IDBP-699192
tRNA-splicing endonuclease subunit Sen2
IDBP-699193
tRNA-splicing endonuclease subunit Sen2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154743:
This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:57274886-57318210
Strand Reverse strand
Band
Transcripts
ENSBTAT00000044043 ENSBTAP00000041560
ENSBTAT00000044041 ENSBTAP00000041558
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000213 tRNA-intron endonuclease activity
GO:0003676 nucleic acid binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
Biological Process
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0000214 tRNA-intron endonuclease complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000154743
View Gene Order
ENSMUSG00000042389
View Gene Order
Cross-References
SwissProt
TrEMBL A6H7E5 Q1PS46
UniProt Splice Variant
Entrez Gene 515511
UniGene
RefSeq XM_005223138 XM_005223139 XM_005223140 NM_001042477
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AH015382 BC146215 DAAA02054586 DAAA02054587 DAAA02054588
GenPept AAI46216 ABB82241
RNA Seq Atlas 515511
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca