Version 5.4
Homo sapiens Gene: LOXL2
Summary
InnateDB Gene IDBG-11841.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LOXL2
Gene Name lysyl oxidase-like 2
Synonyms LOR2; WS9-14
Species Homo sapiens
Ensembl Gene ENSG00000134013
Encoded Proteins
IDBP-11847
lysyl oxidase-like 2
IDBP-807017
lysyl oxidase-like 2
IDBP-484443
lysyl oxidase-like 2
IDBP-475908
lysyl oxidase-like 2
IDBP-485071
lysyl oxidase-like 2
IDBP-484096
lysyl oxidase-like 2
IDBP-480079
lysyl oxidase-like 2
IDBP-480097
lysyl oxidase-like 2
IDBP-475728
lysyl oxidase-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:23297189-23425328
Strand Reverse strand
Band p21.3
Transcripts
ENST00000389131 ENSP00000373783
ENST00000520617
ENST00000523833 ENSP00000473322
ENST00000520349 ENSP00000427907
ENST00000518878 ENSP00000427826
ENST00000522446
ENST00000519809
ENST00000520925
ENST00000518472
ENST00000524144 ENSP00000427883
ENST00000520871 ENSP00000429778
ENST00000518083 ENSP00000430519
ENST00000524168 ENSP00000428497
ENST00000519243 ENSP00000428933
ENST00000524075
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0004720 protein-lysine 6-oxidase activity
GO:0005044 scavenger receptor activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0009055 electron carrier activity
GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
GO:0035064 methylated histone binding
GO:0070492 oligosaccharide binding
Biological Process
GO:0001666 response to hypoxia
GO:0001837 epithelial to mesenchymal transition
GO:0001935 endothelial cell proliferation
GO:0002040 sprouting angiogenesis
GO:0006351 transcription, DNA-templated
GO:0006464 cellular protein modification process
GO:0006898 receptor-mediated endocytosis
GO:0007155 cell adhesion
GO:0007568 aging
GO:0016570 histone modification
GO:0018277 protein deamination
GO:0030199 collagen fibril organization
GO:0032332 positive regulation of chondrocyte differentiation
GO:0043542 endothelial cell migration
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046688 response to copper ion
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005694 chromosome
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034205
View Gene Order
ENSBTAG00000006214
Not yet available
Pathways
NETPATH
REACTOME
REACT_150206
Crosslinking of collagen fibrils pathway
REACT_150180
Assembly of collagen fibrils and other multimeric structures pathway
REACT_150366
Elastic fibre formation pathway
REACT_118779
Extracellular matrix organization pathway
REACT_120729
Collagen formation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.626637 Hs.736854
RefSeq NM_002318
HUGO
OMIM
CCDS CCDS34864
HPRD 09446
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca