InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: LOXL2

Summary

InnateDB Gene

IDBG-635071.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LOXL2

Gene Name

Lysyl oxidase homolog 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006214

Encoded Proteins

IDBP-686887

lysyl oxidase homolog 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134013:
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:71278583-71349786

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000008159

ENSBTAP00000008159

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003714	transcription corepressor activity
GO:0004720	protein-lysine 6-oxidase activity
GO:0005044	scavenger receptor activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
GO:0035064	methylated histone binding
GO:0070492	oligosaccharide binding

Biological Process

GO:0001666	response to hypoxia
GO:0001837	epithelial to mesenchymal transition
GO:0001935	endothelial cell proliferation
GO:0002040	sprouting angiogenesis
GO:0006464	cellular protein modification process
GO:0006898	receptor-mediated endocytosis
GO:0016570	histone modification
GO:0018277	protein deamination
GO:0030199	collagen fibril organization
GO:0032332	positive regulation of chondrocyte differentiation
GO:0043542	endothelial cell migration
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046688	response to copper ion
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000134013

View Gene Order

ENSMUSG00000034205

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_150206

Crosslinking of collagen fibrils pathway

REACT_150180

Assembly of collagen fibrils and other multimeric structures pathway

REACT_150366

Elastic fibre formation pathway

REACT_118779

Extracellular matrix organization pathway

REACT_120729

Collagen formation pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

A6QQC7 M0QVZ4

UniProt Splice Variant

Entrez Gene

532684

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC149766 DAAA02023574 DAAA02023575 DAAA02023576 DAAA02023577 DAAA02023578

GenPept

AAI49767

RNA Seq Atlas

532684