Version 5.4
Bos taurus Gene: SPRED1
Summary
InnateDB Gene IDBG-646185.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPRED1
Gene Name sprouty-related, EVH1 domain-containing protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000032518
Encoded Proteins
IDBP-698964
sprouty-related, EVH1 domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166068:
The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:33950024-34069008
Strand Forward strand
Band
Transcripts
ENSBTAT00000046117 ENSBTAP00000043442
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005173 stem cell factor receptor binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0019902 phosphatase binding
GO:0030291 protein serine/threonine kinase inhibitor activity
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0007275 multicellular organismal development
GO:0009966 regulation of signal transduction
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0010923 negative regulation of phosphatase activity
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0090311 regulation of protein deacetylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000166068
View Gene Order
ENSMUSG00000027351
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_6
KitReceptor pathway
REACTOME
KEGG
hsa04630
Jak-STAT signaling pathway pathway
mmu04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
Cross-References
SwissProt
TrEMBL F1MH60
UniProt Splice Variant
Entrez Gene 519882
UniGene Bt.23265 Bt.72217
RefSeq NM_001192516 XM_005211568
HUGO HGNC:20249
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02028504
GenPept
RNA Seq Atlas 519882

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca