InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Spred1

Summary

InnateDB Gene

IDBG-197685.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spred1

Gene Name

sprouty protein with EVH-1 domain 1, related sequence

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027351

Encoded Proteins

IDBP-197687

sprouty protein with EVH-1 domain 1, related sequence

IDBP-259264

sprouty protein with EVH-1 domain 1, related sequence

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166068:
The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:117121374-117182279

Strand

Forward strand

Band

Transcripts

ENSMUST00000028829	ENSMUSP00000028829
ENSMUST00000110901	ENSMUSP00000106526

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005173	stem cell factor receptor binding
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0019902	phosphatase binding
GO:0030291	protein serine/threonine kinase inhibitor activity

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0007275	multicellular organismal development
GO:0009966	regulation of signal transduction
GO:0010801	negative regulation of peptidyl-threonine phosphorylation
GO:0010923	negative regulation of phosphatase activity
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0090311	regulation of protein deacetylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005901	caveola
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000166068

View Gene Order

ENSBTAG00000032518

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04630

Jak-STAT signaling pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_6

KitReceptor pathway

REACTOME

KEGG

hsa04630

Jak-STAT signaling pathway pathway

INOH

PID NCI

kitpathway

Signaling events mediated by Stem cell factor receptor (c-Kit)

Cross-References

SwissProt

Q924S8

TrEMBL

UniProt Splice Variant

Entrez Gene

114715

UniGene

Mm.245890 Mm.386134 Mm.392720 Mm.392726 Mm.397626 Mm.405729

RefSeq

NM_001277256 NM_033524

OMIM

CCDS

CCDS71115 CCDS16570

HPRD

IMGT

MGI ID

MGI:2150016

MGI Symbol

Spred1

EMBL

AB063495 AK155065 AL807741 AL928959 BC057874 BC079606

GenPept

AAH57874 AAH79606 BAB62848 BAE33024 CAM17918 CAM26783

RNA Seq Atlas

114715