InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spred1

Summary

InnateDB Protein

IDBP-197687.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spred1

Protein Name

sprouty protein with EVH-1 domain 1, related sequence

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028829

InnateDB Gene

IDBG-197685 (Spred1)

Protein Structure

UniProt Annotation

Function

Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow. {ECO:0000269PubMed:11493923, ECO:0000269PubMed:15465815}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:11493923}; Peripheral membrane protein {ECO:0000269PubMed:11493923}. Membrane, caveola {ECO:0000269PubMed:11493923}; Peripheral membrane protein {ECO:0000269PubMed:11493923}. Nucleus {ECO:0000269PubMed:11493923}. Note=Localized in cholesterol-rich membrane raft/caveola fractions. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain. Weakly expressed in lung, heart, liver, kidney, intestine, spleen, testis, thymus, colon and ovary. Also expressed in embryonic tissues such as heart, lung, liver and brain. Highly expressed in IL3-dependent hematopoietic cell lines (Ba/F3 and MC/9) and bone marrow-derived mast cells (BMMC). {ECO:0000269PubMed:11493923, ECO:0000269PubMed:12646235, ECO:0000269PubMed:15465815, ECO:0000269PubMed:15580519}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005173	stem cell factor receptor binding
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0019902	phosphatase binding
GO:0030291	protein serine/threonine kinase inhibitor activity

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0007275	multicellular organismal development
GO:0009966	regulation of signal transduction
GO:0010801	negative regulation of peptidyl-threonine phosphorylation
GO:0010923	negative regulation of phosphatase activity
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0090311	regulation of protein deacetylation