Version 5.4
Bos taurus Gene: PPARGC1A
Summary
InnateDB Gene IDBG-641316.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPARGC1A
Gene Name Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000017024
Encoded Proteins
IDBP-693672
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
IDBP-693675
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 21966468
[Homo sapiens] PPARGC1A is activated in Staphylococcus aureus-mediated sepsis via the TLR2-signalling pathway. (Demonstrated in mice)
PMID 25595716
[Homo sapiens] MIR130A reduces hepatitis B virus (HBV) replication by down-regulating the expression of two major metabolic regulators PPARGC1A and PPARG, both of which can potently stimulate HBV replication.
PMID 21966468
[Mus musculus] Ppargc1a is activated in Staphylococcus aureus-mediated sepsis via the Tlr2-signalling pathway.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109819:
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:44854113-44960668
Strand Reverse strand
Band
Transcripts
ENSBTAT00000022636 ENSBTAP00000022636
ENSBTAT00000055094 ENSBTAP00000048844
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.
Predicted by orthology
Total 58 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016922 ligand-dependent nuclear receptor binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0031490 chromatin DNA binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0010822 positive regulation of mitochondrion organization
GO:0010941 regulation of cell death
GO:0014850 response to muscle activity
GO:0022904 respiratory electron transport chain
GO:0032922 circadian regulation of gene expression
GO:0034599 cellular response to oxidative stress
GO:0042752 regulation of circadian rhythm
GO:0043524 negative regulation of neuron apoptotic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048511 rhythmic process
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0070997 neuron death
GO:1901857 positive regulation of cellular respiration
GO:1901860 positive regulation of mitochondrial DNA metabolic process
GO:1901863 positive regulation of muscle tissue development
GO:2000507 positive regulation of energy homeostasis
GO:2001171 positive regulation of ATP biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0016605 PML body
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000109819
View Gene Order
ENSMUSG00000029167
View Gene Order
Pathways
NETPATH
REACTOME
REACT_207951
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_214581
Transcriptional activation of mitochondrial biogenesis pathway
REACT_212213
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
REACT_220799
Transcriptional regulation of white adipocyte differentiation pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
REACT_224346
REV-ERBA represses gene expression pathway
REACT_207237
PPARA activates gene expression pathway
REACT_226458
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_205675
Mitochondrial biogenesis pathway
REACT_215625
RORA activates circadian gene expression pathway
REACT_210271
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_220844
Developmental Biology pathway
REACT_227144
Circadian Clock pathway
REACT_219259
Organelle biogenesis and maintenance pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_118659
RORA activates circadian gene expression pathway
REACT_111118
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_118789
REV-ERBA represses gene expression pathway
REACT_24941
Circadian Clock pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_111045
Developmental Biology pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_200686
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
REACT_111217
Metabolism pathway
REACT_27166
Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes pathway
REACT_118837
Rora activates circadian gene expression pathway
REACT_24972
Circadian Clock pathway
REACT_252217
Transcriptional regulation of white adipocyte differentiation pathway
REACT_224594
Organelle biogenesis and maintenance pathway
REACT_200794
Mus musculus biological processes pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_241925
Circadian Clock pathway
REACT_198352
REV-ERBA represses gene expression pathway
REACT_198351
RORA activates circadian gene expression pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_257219
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_205251
Transcriptional activation of mitochondrial biogenesis pathway
REACT_198602
PPARA activates gene expression pathway
REACT_188576
Developmental Biology pathway
REACT_211261
Mitochondrial biogenesis pathway
REACT_205688
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
KEGG
hsa04910
Insulin signaling pathway pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa05016
Huntington's disease pathway
mmu04910
Insulin signaling pathway pathway
mmu04920
Adipocytokine signaling pathway pathway
mmu05016
Huntington's disease pathway
INOH
PID NCI
mtor_4pathway
mTOR signaling pathway
atf2_pathway
ATF-2 transcription factor network
hdac_classiii_pathway
Signaling events mediated by HDAC Class III
p38alphabetadownstreampathway
Signaling mediated by p38-alpha and p38-beta
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.20920
RefSeq NM_177945 XM_005207759 XM_005207760 XM_005207761 XM_005207762
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca