Version 5.4
Bos taurus Protein: PPARGC1A
Summary
InnateDB Protein IDBP-693675.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPARGC1A
Protein Name Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000048844
InnateDB Gene IDBG-641316 (PPARGC1A)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.
Predicted by orthology
Total 58 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016922 ligand-dependent nuclear receptor binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0031490 chromatin DNA binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0010822 positive regulation of mitochondrion organization
GO:0010941 regulation of cell death
GO:0014850 response to muscle activity
GO:0022904 respiratory electron transport chain
GO:0032922 circadian regulation of gene expression
GO:0034599 cellular response to oxidative stress
GO:0042752 regulation of circadian rhythm
GO:0043524 negative regulation of neuron apoptotic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048511 rhythmic process
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0070997 neuron death
GO:1901857 positive regulation of cellular respiration
GO:1901860 positive regulation of mitochondrial DNA metabolic process
GO:1901863 positive regulation of muscle tissue development
GO:2000507 positive regulation of energy homeostasis
GO:2001171 positive regulation of ATP biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0016605 PML body
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL B6DXN4
UniProt Splice Variant
Entrez Gene 338446
UniGene Bt.20920
RefSeq XP_005207816
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB106107 AY321517 BC151326 DAAA02017101 FJ177640
GenPept AAI51327 AAQ82595 ACI42873 BAC66018

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca