InnateDB Protein
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IDBP-693672.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PPARGC1A
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Protein Name
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Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000022636
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InnateDB Gene
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IDBG-641316 (PPARGC1A)
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Protein Structure
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Function |
Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
58 [view]
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0010822
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positive regulation of mitochondrion organization
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GO:0010941
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regulation of cell death
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GO:0014850
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response to muscle activity
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GO:0022904
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respiratory electron transport chain
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GO:0032922
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circadian regulation of gene expression
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GO:0034599
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cellular response to oxidative stress
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GO:0042752
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regulation of circadian rhythm
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GO:0043524
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negative regulation of neuron apoptotic process
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0048511
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rhythmic process
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GO:0051091
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positive regulation of sequence-specific DNA binding transcription factor activity
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GO:0070997
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neuron death
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GO:2000507
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positive regulation of energy homeostasis
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GO:2001171
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positive regulation of ATP biosynthetic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
Q865B7
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PhosphoSite |
PhosphoSite-
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TrEMBL |
B6DXN4
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UniProt Splice Variant |
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Entrez Gene |
338446
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UniGene |
Bt.20920
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RefSeq |
NP_808814
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AB106107
AY321517
FJ177640
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GenPept |
AAQ82595
ACI42873
BAC66018
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