Version 5.4
Mus musculus Gene: Brwd1
Summary
InnateDB Gene IDBG-179349.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Brwd1
Gene Name bromodomain and WD repeat domain containing 1
Synonyms 5330419I02Rik; D530019K20Rik; G1-403-16; repro5; Wdr9
Species Mus musculus
Ensembl Gene ENSMUSG00000022914
Encoded Proteins
IDBP-179351
bromodomain and WD repeat domain containing 1
IDBP-179353
bromodomain and WD repeat domain containing 1
IDBP-253045
bromodomain and WD repeat domain containing 1
IDBP-253047
bromodomain and WD repeat domain containing 1
IDBP-534208
bromodomain and WD repeat domain containing 1
IDBP-541402
bromodomain and WD repeat domain containing 1
IDBP-532529
bromodomain and WD repeat domain containing 1
IDBP-532952
bromodomain and WD repeat domain containing 1
IDBP-540886
bromodomain and WD repeat domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185658:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:95992092-96082526
Strand Reverse strand
Band C4
Transcripts
ENSMUST00000023631 ENSMUSP00000023631
ENSMUST00000099502 ENSMUSP00000097101
ENSMUST00000113829 ENSMUSP00000109460
ENSMUST00000113827 ENSMUSP00000109458
ENSMUST00000153398 ENSMUSP00000117066
ENSMUST00000131322 ENSMUSP00000118327
ENSMUST00000156622
ENSMUST00000157037
ENSMUST00000127777
ENSMUST00000152197 ENSMUSP00000122457
ENSMUST00000147655
ENSMUST00000130823
ENSMUST00000148432
ENSMUST00000124370 ENSMUSP00000118423
ENSMUST00000139566 ENSMUSP00000121141
ENSMUST00000126629
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007010 cytoskeleton organization
GO:0008360 regulation of cell shape
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000185658
View Gene Order
ENSBTAG00000013602
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.240871 Mm.408818 Mm.415767
RefSeq NM_001103179 NM_145125 NM_176928 XM_006523113 XM_006536897
OMIM
CCDS CCDS49922 CCDS49923
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca