Version 5.4
Mus musculus Protein: Brwd1
Summary
InnateDB Protein IDBP-253045.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Brwd1
Protein Name bromodomain and WD repeat domain containing 1
Synonyms 5330419I02Rik; D530019K20Rik; G1-403-16; repro5; Wdr9;
Species Mus musculus
Ensembl Protein ENSMUSP00000109460
InnateDB Gene IDBG-179349 (Brwd1)
Protein Structure
UniProt Annotation
Function May be a transcriptional activator. May be involved in chromatin remodeling. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000269PubMed:12889071}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:12889071}. Nucleus {ECO:0000269PubMed:12889071}.
Disease Associations
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:12359327}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007010 cytoskeleton organization
GO:0008360 regulation of cell shape
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1890651
InterPro IPR001487 Bromodomain
IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00439
PF00400
PRINTS PR00503
PIRSF
SMART SM00297
SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q921C3
PhosphoSite PhosphoSite-Q921C3
TrEMBL Q3UMZ7
UniProt Splice Variant
Entrez Gene 93871
UniGene Mm.415767
RefSeq
MGI ID
MGI Symbol Brwd1
OMIM
CCDS
HPRD
IMGT
EMBL AC144797 AC152502 AJ292467 AJ292468 AK144589 AK162170
GenPept BAE25951 BAE36768 CAC44373 CAC44374

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca