Version 5.4
Mus musculus Gene: Gart
Summary
InnateDB Gene IDBG-176236.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gart
Gene Name phosphoribosylglycinamide formyltransferase
Synonyms Gaps; Prgs
Species Mus musculus
Ensembl Gene ENSMUSG00000022962
Encoded Proteins
IDBP-176238
phosphoribosylglycinamide formyltransferase
IDBP-400869
phosphoribosylglycinamide formyltransferase
IDBP-534747
phosphoribosylglycinamide formyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159131:
The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:91621186-91646952
Strand Reverse strand
Band C3.3
Transcripts
ENSMUST00000023684 ENSMUSP00000023684
ENSMUST00000120450 ENSMUSP00000114034
ENSMUST00000156713 ENSMUSP00000119272
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004637 phosphoribosylamine-glycine ligase activity
GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity
GO:0004644 phosphoribosylglycinamide formyltransferase activity
GO:0005524 ATP binding
GO:0008168 methyltransferase activity
GO:0016742 hydroxymethyl-, formyl- and related transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0003360 brainstem development
GO:0006189 'de novo' IMP biosynthetic process
GO:0006544 glycine metabolic process
GO:0009058 biosynthetic process
GO:0009113 purine nucleobase biosynthetic process
GO:0009156 ribonucleoside monophosphate biosynthetic process
GO:0010033 response to organic substance
GO:0010035 response to inorganic substance
GO:0021549 cerebellum development
GO:0021987 cerebral cortex development
GO:0032259 methylation
GO:0046654 tetrahydrofolate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000159131
View Gene Order
ENSBTAG00000009188
Not yet available
Pathways
NETPATH
REACTOME
REACT_263730
Purine metabolism pathway
REACT_188937
Metabolism pathway
REACT_263184
Purine ribonucleoside monophosphate biosynthesis pathway
REACT_245662
Metabolism of nucleotides pathway
KEGG
mmu00670
One carbon pool by folate pathway
mmu00230
Purine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1776
Purine ribonucleoside monophosphate biosynthesis pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_522
Purine metabolism pathway
REACT_111217
Metabolism pathway
REACT_210940
Metabolism of nucleotides pathway
REACT_205922
Purine metabolism pathway
REACT_219139
Metabolism pathway
REACT_226478
Purine ribonucleoside monophosphate biosynthesis pathway
KEGG
hsa00670
One carbon pool by folate pathway
hsa00230
Purine metabolism pathway
INOH
INOH website
Folate metabolism pathway
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt Q64737
TrEMBL Q3TH49
UniProt Splice Variant
Entrez Gene 14450
UniGene Mm.4505 Mm.486516
RefSeq XM_006522913 NM_010256 XM_006522910 XM_006522911 XM_006522912
OMIM
CCDS CCDS28329
HPRD
IMGT
MGI ID MGI:95654
MGI Symbol Gart
EMBL AK168445 AK168501 AK168724 AK168796 AK168864 AK168876 BC070465 CH466602 U01023 U01024 U20875 U20876 U20877 U20879 U20880 U20881 U20882 U20883 U20884 U20885 U20886 U20887 U20889 U20890 U20891 U20892
GenPept AAA19012 AAA19013 AAC53250 AAC53251 AAH70465 BAE40349 BAE40386 BAE40565 BAE40629 BAE40683 BAE40694 EDL03819
RNA Seq Atlas 14450

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca