InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GART

Summary

InnateDB Gene

IDBG-629787.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GART

Gene Name

Trifunctional purine biosynthetic protein adenosine-3 Phosphoribosylamine--glycine ligase Phosphoribosylformylglycinamidine cyclo-ligase Phosphoribosylglycinamide formyltransferase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009188

Encoded Proteins

IDBP-681222

Trifunctional purine biosynthetic protein adenosine-3Phosphoribosylamine--glycine ligasePhosphoribosylformylglycinamidine cyclo-ligasePhosphoribosylglycinamide formyltransferase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159131:
The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:1265743-1292028

Strand

Forward strand

Band

Transcripts

ENSBTAT00000012108

ENSBTAP00000012108

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003824	catalytic activity
GO:0004637	phosphoribosylamine-glycine ligase activity
GO:0004641	phosphoribosylformylglycinamidine cyclo-ligase activity
GO:0004644	phosphoribosylglycinamide formyltransferase activity
GO:0005524	ATP binding
GO:0008168	methyltransferase activity
GO:0016740	transferase activity
GO:0016742	hydroxymethyl-, formyl- and related transferase activity
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0006164	purine nucleotide biosynthetic process
GO:0006189	'de novo' IMP biosynthetic process
GO:0008152	metabolic process
GO:0009058	biosynthetic process
GO:0009113	purine nucleobase biosynthetic process
GO:0032259	methylation