InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rangap1

Summary

InnateDB Gene

IDBG-165134.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rangap1

Gene Name

RAN GTPase activating protein 1

Synonyms

C79654; Fug1; mKIAA1835

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022391

Encoded Proteins

IDBP-165136

RAN GTPase activating protein 1

IDBP-622073

RAN GTPase activating protein 1

IDBP-622081

RAN GTPase activating protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100401:
RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. [provided by RefSeq, Jul 2008]
This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:81704248-81729919

Strand

Reverse strand

Band

Transcripts

ENSMUST00000052374	ENSMUSP00000057771
ENSMUST00000170134	ENSMUSP00000126849
ENSMUST00000171115	ENSMUSP00000130046

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005098	Ran GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0032853	positive regulation of Ran GTPase activity
GO:0046826	negative regulation of protein export from nucleus

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0031965	nuclear membrane
GO:0048471	perinuclear region of cytoplasm