InnateDB Protein
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IDBP-622073.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rangap1
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Protein Name
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RAN GTPase activating protein 1
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Synonyms
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C79654; Fug1; mKIAA1835;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000126849
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InnateDB Gene
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IDBG-165134 (Rangap1)
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Protein Structure
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Function |
GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Required for postimplantation development. {ECO:0000269PubMed:16469311, ECO:0000269PubMed:9442102, ECO:0000269PubMed:9456312}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Cytoplasmic during interphase. Targeted to the nuclear rim after sumoylation. During mitosis, associates with mitotic spindles. Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase. Mitotic location also requires sumoylation (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
Experimentally validated |
Total |
18
[view]
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Protein-Protein |
17
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
42 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:103071
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InterPro |
IPR003590
Leucine-rich repeat, ribonuclease inhibitor subtype
IPR009109
Ran-GTPase activating protein 1, C-terminal
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PFAM |
PF07834
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PRINTS |
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PIRSF |
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SMART |
SM00368
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TIGRFAMs |
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Modification |
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SwissProt |
P46061
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PhosphoSite |
PhosphoSite-P46061
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TrEMBL |
Q9CW20
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UniProt Splice Variant |
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Entrez Gene |
19387
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UniGene |
Mm.475271
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RefSeq |
NP_035371
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MGI ID |
1KPS
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MGI Symbol |
Rangap1
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OMIM |
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CCDS |
CCDS27670
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HPRD |
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IMGT |
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EMBL |
AK005370
AK146670
AK159009
AK159525
BC066213
BC071200
U08110
U20857
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GenPept |
AAA17681
AAB60517
AAH66213
AAH71200
BAB23979
BAE27347
BAE34767
BAE35154
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