Version 5.4
Mus musculus Protein: Rangap1
Summary
InnateDB Protein IDBP-165136.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rangap1
Protein Name RAN GTPase activating protein 1
Synonyms C79654; Fug1; mKIAA1835;
Species Mus musculus
Ensembl Protein ENSMUSP00000057771
InnateDB Gene IDBG-165134 (Rangap1)
Protein Structure
UniProt Annotation
Function GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Required for postimplantation development. {ECO:0000269PubMed:16469311, ECO:0000269PubMed:9442102, ECO:0000269PubMed:9456312}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Cytoplasmic during interphase. Targeted to the nuclear rim after sumoylation. During mitosis, associates with mitotic spindles. Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase. Mitotic location also requires sumoylation (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 42 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005098 Ran GTPase activator activity
Biological Process
GO:0007165 signal transduction
GO:0032853 positive regulation of Ran GTPase activity
GO:0046826 negative regulation of protein export from nucleus
Cellular Component
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0031965 nuclear membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:103071
InterPro IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
IPR009109 Ran-GTPase activating protein 1, C-terminal
PFAM PF07834
PRINTS
PIRSF
SMART SM00368
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P46061
PhosphoSite PhosphoSite-P46061
TrEMBL Q9CW20
UniProt Splice Variant
Entrez Gene 19387
UniGene Mm.475271
RefSeq NP_001139646
MGI ID 1KPS
MGI Symbol Rangap1
OMIM
CCDS CCDS27670
HPRD
IMGT
EMBL AK005370 AK146670 AK159009 AK159525 BC066213 BC071200 U08110 U20857
GenPept AAA17681 AAB60517 AAH66213 AAH71200 BAB23979 BAE27347 BAE34767 BAE35154

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca