InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HIRA

Summary

InnateDB Gene

IDBG-1317.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HIRA

Gene Name

HIR histone cell cycle regulation defective homolog A (S. cerevisiae)

Synonyms

DGCR1; TUP1; TUPLE1

Species

Homo sapiens

Ensembl Gene

ENSG00000100084

Encoded Proteins

IDBP-1319

HIR histone cell cycle regulation defective homolog A (S. cerevisiae)

IDBP-1321

HIR histone cell cycle regulation defective homolog A (S. cerevisiae)

IDBP-361715

HIR histone cell cycle regulation defective homolog A (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:19330698-19447450

Strand

Reverse strand

Band

q11.21

Transcripts

ENST00000263208	ENSP00000263208
ENST00000340170	ENSP00000345350
ENST00000452818	ENSP00000404792
ENST00000464189

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0006336	DNA replication-independent nucleosome assembly
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007369	gastrulation
GO:0009653	anatomical structure morphogenesis
GO:0016568	chromatin modification
GO:0042692	muscle cell differentiation

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0016605	PML body
GO:0043234	protein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022702

View Gene Order

ENSBTAG00000019888

Not yet available

Pathways

NETPATH

REACTOME

REACT_120956

Cellular responses to stress pathway

REACT_169121

Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway

REACT_169185

DNA Damage/Telomere Stress Induced Senescence pathway

REACT_169274

Cellular Senescence pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

P54198

TrEMBL

F5H4M2

UniProt Splice Variant

Entrez Gene

7290

UniGene

Hs.474206

RefSeq

NM_003325

HUGO

HGNC:4916

OMIM

600237

CCDS

CCDS13759

HPRD

IMGT

EMBL

AC000068 AC000079 AC000085 AC000092 BC032721 BC039835 CR456503 X75296 X77633 X81844 X89887 X91501

GenPept

AAH32721 AAH39835 CAA53044 CAA54721 CAA57436 CAA61979 CAA62800 CAG30389

RNA Seq Atlas

7290