Version 5.4
Bos taurus Gene: HIRA
Summary
InnateDB Gene IDBG-638015.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIRA
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019888
Encoded Proteins
IDBP-690117
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100084:
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:74663544-74697337
Strand Reverse strand
Band
Transcripts
ENSBTAT00000026497 ENSBTAP00000026497
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0006336 DNA replication-independent nucleosome assembly
GO:0006355 regulation of transcription, DNA-templated
GO:0007369 gastrulation
GO:0016568 chromatin modification
GO:0042692 muscle cell differentiation
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000100084
View Gene Order
ENSMUSG00000022702
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_169121
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
REACT_169185
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_169274
Cellular Senescence pathway
REACT_188957
Cellular responses to stress pathway
REACT_188819
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_188820
Cellular Senescence pathway
REACT_209428
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1N3C8
UniProt Splice Variant
Entrez Gene 101906870
UniGene Bt.53751
RefSeq XM_005195159 XM_005195160 XM_005195161 XM_005195162 XM_005218307 XM_005218308 XM_005218309 XM_005218310
HUGO HGNC:4916
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02045759
GenPept
RNA Seq Atlas 101906870

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca