InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HIRA

Summary

InnateDB Protein

IDBP-1321.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HIRA

Protein Name

HIR histone cell cycle regulation defective homolog A (S. cerevisiae)

Synonyms

DGCR1; TUP1; TUPLE1;

Species

Homo sapiens

Ensembl Protein

ENSP00000345350

InnateDB Gene

IDBG-1317 (HIRA)

Protein Structure

UniProt Annotation

Function

Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269PubMed:12370293, ECO:0000269PubMed:14718166, ECO:0000269PubMed:15621527}.

Subcellular Localization

Nucleus. Nucleus, PML body. Note=Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.

Disease Associations

Tissue Specificity

Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta. {ECO:0000269PubMed:9063745}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding

Biological Process

GO:0006336	DNA replication-independent nucleosome assembly
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0009653	anatomical structure morphogenesis
GO:0016568	chromatin modification