Version 5.4
Bos taurus Protein: TOLLIP
Summary
InnateDB Protein IDBP-698343.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOLLIP
Protein Name Toll-interacting protein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000010835
InnateDB Gene IDBG-645625 (TOLLIP)
Protein Structure
UniProt Annotation
Function Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.
Predicted by orthology
Total 60 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019900 kinase binding
GO:0035325 Toll-like receptor binding
Biological Process
GO:0002376 immune system process
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0016310 phosphorylation
GO:0030855 epithelial cell differentiation
GO:0036010 protein localization to endosome
GO:0045087 innate immune response
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
IPR003892 Ubiquitin system component Cue
IPR009060 UBA-like
PFAM PF00168
PF02845
PRINTS PR00360
PIRSF
SMART SM00239
SM00546
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2LGB5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 539480
UniGene Bt.10935
RefSeq NP_001035050
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123457 BT021785 DQ319073 DQ407275
GenPept AAI23458 AAX46632 ABC47876 ABD72515

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca