Bos taurus Gene: TOLLIP | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Gene | IDBG-645625.3 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | TOLLIP | ||||||||||||||
Gene Name | Toll-interacting protein | ||||||||||||||
Synonyms | |||||||||||||||
Species | Bos taurus | ||||||||||||||
Ensembl Gene | ENSBTAG00000008237 | ||||||||||||||
Encoded Proteins |
Toll-interacting protein
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Protein Structure | |||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||
Summary |
[Homo sapiens] TOLLIP is a negative regulator of toll-like receptor (TLR) mediated signalling which serves to limit the production of pro-inflammatory mediators during inflammation and infection.
[Homo sapiens] TOLLIP over-expression inhibits activation of NF-kappaB in response to IL1, the TLR2 and TLR4 ligands.
[Homo sapiens] TOLLIP/IRAK1/TRAF6 complex formation is positively regulated by RCAN1 (DSCR1) short isoform, resulting in the modulation of IL-1R-mediated signalling pathways.
[Mus musculus] Super-low dose lipopolysaccharide induces inhibitory phosphorylation of Pik3c3 leading to the disruption of endosome-lysosome fusion and low-grade inflammation in innate macrophages; a mechanism that depends on the clearance and relocation of Tollip.
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Entrez Gene | |||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078902:
This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. [provided by RefSeq, Aug 2011] |
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Gene Information | |||||||||||||||
Type | Protein coding | ||||||||||||||
Genomic Location | Chromosome 29:51319497-51335168 | ||||||||||||||
Strand | Forward strand | ||||||||||||||
Band | |||||||||||||||
Transcripts |
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Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathways | |||||||||||||||
NETPATH | |||||||||||||||
REACTOME |
Cytokine Signaling in Immune system pathway
Immune System pathway
Interleukin-1 signaling pathway
Signaling by Interleukins pathway
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KEGG | |||||||||||||||
INOH | |||||||||||||||
PID NCI | |||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||
NETPATH |
EGFR1 pathway
IL1 pathway
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REACTOME |
Interleukin-1 signaling pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Signaling by Interleukins pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Signaling by Interleukins pathway
Interleukin-1 signaling pathway
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KEGG |
Toll-like receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
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INOH |
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
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PID NCI |
IL1-mediated signaling events
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Cross-References | |||||||||||||||
SwissProt | Q2LGB5 | ||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 539480 | ||||||||||||||
UniGene | Bt.10935 | ||||||||||||||
RefSeq | NM_001039961 | ||||||||||||||
HUGO | |||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | BC123457 BT021785 DQ319073 DQ407275 | ||||||||||||||
GenPept | AAI23458 AAX46632 ABC47876 ABD72515 | ||||||||||||||
RNA Seq Atlas | 539480 | ||||||||||||||