Version 5.4
Bos taurus Protein: TNFRSF1A
Summary
InnateDB Protein IDBP-692780.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFRSF1A
Protein Name tumor necrosis factor receptor superfamily member 1A precursor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000005522
InnateDB Gene IDBG-640513 (TNFRSF1A)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 168 interaction(s) predicted by orthology.
Predicted by orthology
Total 168 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005031 tumor necrosis factor-activated receptor activity
GO:0005515 protein binding
Biological Process
GO:0006693 prostaglandin metabolic process
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0019221 cytokine-mediated signaling pathway
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042742 defense response to bacterium
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050728 negative regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0071260 cellular response to mechanical stimulus
Cellular Component
GO:0000139 Golgi membrane
GO:0005615 extracellular space
GO:0043235 receptor complex
GO:0045121 membrane raft
Protein Structure and Domains
PDB ID
InterPro IPR000488 Death domain
IPR001368 TNFR/NGFR cysteine-rich region
IPR011029 Death-like domain
IPR020419 Tumour necrosis factor receptor 1A
PFAM PF00531
PF00020
PRINTS PR01918
PIRSF
SMART SM00005
SM00208
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MSX5
UniProt Splice Variant
Entrez Gene 282527
UniGene Bt.3890
RefSeq NP_777099
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02014475
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca