InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TNFRSF1A

Summary

InnateDB Gene

IDBG-640513.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFRSF1A

Gene Name

tumor necrosis factor receptor superfamily member 1A precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004211

Encoded Proteins

IDBP-692780

tumor necrosis factor receptor superfamily member 1A precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 12753742

[Homo sapiens] Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation

PMID 19150425

[Homo sapiens] TNFR1 mediates TRAF2 phosphorylation and recruitment of the IKK complex

PMID 21802165

[Homo sapiens] TNFRSF1A modulates nitric oxide production in peritoneal macrophages in response to Yersinia LPS stimulation through the IL6 and NFkB signalling pathway. (Demonstrated in mouse)

PMID 21802165

[Mus musculus] Tnfrsf1a modulates nitric oxide production in peritoneal macrophages in response to Yersinia LPS stimulation through the Il6 and NFkB signalling pathway.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067182:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:104402771-104415588

Strand

Forward strand

Band

Transcripts

ENSBTAT00000005522

ENSBTAP00000005522

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 168 interaction(s) predicted by orthology.

Predicted by orthology
Total	168 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005031	tumor necrosis factor-activated receptor activity
GO:0005515	protein binding

Biological Process

GO:0006693	prostaglandin metabolic process
GO:0006952	defense response
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0019221	cytokine-mediated signaling pathway
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042742	defense response to bacterium
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050728	negative regulation of inflammatory response
GO:0050729	positive regulation of inflammatory response
GO:0071260	cellular response to mechanical stimulus