InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SIK1

Summary

InnateDB Protein

IDBP-692001.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SIK1

Protein Name

salt-inducible kinase 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000015200

InnateDB Gene

IDBG-639805 (SIK1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008140	cAMP response element binding protein binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0042826	histone deacetylase binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007346	regulation of mitotic cell cycle
GO:0010830	regulation of myotube differentiation
GO:0010868	negative regulation of triglyceride biosynthetic process
GO:0032792	negative regulation of CREB transcription factor activity
GO:0035556	intracellular signal transduction
GO:0043276	anoikis
GO:0045595	regulation of cell differentiation
GO:0045721	negative regulation of gluconeogenesis
GO:0055007	cardiac muscle cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00165
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

E1BNS8

UniProt Splice Variant

Entrez Gene

100337254

UniGene

RefSeq

XP_002685202

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02003460 DAAA02003461 DAAA02003462 DAAA02003463

GenPept