InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: DPYSL2

Summary

InnateDB Protein

IDBP-687480.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DPYSL2

Protein Name

Dihydropyrimidinase-related protein 2

Synonyms

CRMP-2; DRP-2; TOAD-64;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000024448

InnateDB Gene

IDBG-635631 (DPYSL2)

Protein Structure

UniProt Annotation

Function

Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Membrane {ECO:0000250}. Note=Tightly but non-covalently associated with membranes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO:0019901	protein kinase binding

Biological Process

GO:0006208	pyrimidine nucleobase catabolic process
GO:0006897	endocytosis
GO:0007010	cytoskeleton organization
GO:0007275	multicellular organismal development
GO:0007399	nervous system development
GO:0030154	cell differentiation

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005874	microtubule
GO:0016020	membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR006680 Amidohydrolase 1
IPR011059 Metal-dependent hydrolase, composite domain
IPR011778 Hydantoinase/dihydropyrimidinase

PFAM

PF01979

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O02675

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

533746

UniGene

Bt.97972

RefSeq

NP_001069468

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC114153 U83278

GenPept

AAB80618 AAI14154