InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DPYSL2

Summary

InnateDB Gene

IDBG-635631.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DPYSL2

Gene Name

Dihydropyrimidinase-related protein 2

Synonyms

CRMP-2; DRP-2; TOAD-64

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018373

Encoded Proteins

IDBP-687480

Dihydropyrimidinase-related protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092964:
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer\'s disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:75089346-75168436

Strand

Forward strand

Band

Transcripts

ENSBTAT00000024448

ENSBTAP00000024448

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO:0019901	protein kinase binding

Biological Process

GO:0006208	pyrimidine nucleobase catabolic process
GO:0006897	endocytosis
GO:0007010	cytoskeleton organization
GO:0007275	multicellular organismal development
GO:0007399	nervous system development
GO:0030154	cell differentiation

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005874	microtubule
GO:0016020	membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0070062	extracellular vesicular exosome