Version 5.4
Homo sapiens Protein: CYTH4
Summary
InnateDB Protein IDBP-6546.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYTH4
Protein Name cytohesin 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000248901
InnateDB Gene IDBG-6544 (CYTH4)
Protein Structure
UniProt Annotation
Function Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP. {ECO:0000269PubMed:10652308}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:17398095}; Peripheral membrane protein {ECO:0000269PubMed:17398095}.
Disease Associations
Tissue Specificity Expressed predominantly in peripheral blood leukocytes. {ECO:0000269PubMed:10652308}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0008289 lipid binding
Biological Process
GO:0030155 regulation of cell adhesion
GO:0032012 regulation of ARF protein signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR000904 Sec7 domain
IPR001849 Pleckstrin homology domain
PFAM PF01369
PF00169
PRINTS
PIRSF
SMART SM00222
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UIA0
PhosphoSite PhosphoSite-Q9UIA0
TrEMBL Q8WWE8
UniProt Splice Variant
Entrez Gene 27128
UniGene
RefSeq NP_037517
HUGO HGNC:9505
OMIM 606514
CCDS CCDS13946
HPRD 07354
IMGT
EMBL AF075458 AF125349 AK304453 BC017780 BC041161 CR456551 Z94160
GenPept AAF15389 AAF28896 AAH17780 AAH41161 BAG65270 CAG30437 CAI22121

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca