Version 5.4
Homo sapiens Gene: CYTH4
Summary
InnateDB Gene IDBG-6544.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYTH4
Gene Name cytohesin 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000100055
Encoded Proteins
IDBP-6546
cytohesin 4
IDBP-293858
cytohesin 4
IDBP-293862
cytohesin 4
IDBP-375291
cytohesin 4
IDBP-375331
cytohesin 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with both ARF1 and ARF5 but is inactive with ARF6. The structures of this gene and CYTH1 are very similar. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:37282027-37315345
Strand Forward strand
Band q13.1
Transcripts
ENST00000248901 ENSP00000248901
ENST00000405206 ENSP00000384280
ENST00000402997 ENSP00000385997
ENST00000457992 ENSP00000405442
ENST00000439667
ENST00000447919
ENST00000446506 ENSP00000409579
ENST00000469886
ENST00000462927
ENST00000480510
ENST00000467664
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0008289 lipid binding
Biological Process
GO:0030155 regulation of cell adhesion
GO:0032012 regulation of ARF protein signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018008
View Gene Order
ENSBTAG00000014237
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL B1AHH4 B1AHH5 Q8WWE8
UniProt Splice Variant
Entrez Gene 27128
UniGene
RefSeq NM_013385
HUGO HGNC:9505
OMIM 606514
CCDS CCDS13946
HPRD 07354
IMGT
EMBL BC017780 Z94160
GenPept AAH17780
RNA Seq Atlas 27128

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca