Version 5.4
Mus musculus Protein: Adamts1
Summary
InnateDB Protein IDBP-539969.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Adamts1
Protein Name a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
Synonyms ADAM-TS1; ADAMTS; ADAMTS-1; C3-C5; METH-1; METH1;
Species Mus musculus
Ensembl Protein ENSMUSP00000118471
InnateDB Gene IDBG-173182 (Adamts1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0008270 zinc ion binding
Biological Process
GO:0001542 ovulation from ovarian follicle
GO:0001822 kidney development
GO:0006508 proteolysis
GO:0016525 negative regulation of angiogenesis
GO:0060347 heart trabecula formation
Cellular Component
GO:0005604 basement membrane
GO:0031012 extracellular matrix
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID MGI:109249
InterPro IPR000884 Thrombospondin, type 1 repeat
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR006586 ADAM, cysteine-rich
IPR010294 ADAM-TS Spacer 1
IPR013273 Peptidase M12B, ADAM-TS
IPR013274 Peptidase M12B, ADAM-TS1
PFAM PF00090
PF01421
PF08516
PF05986
PRINTS PR01857
PR01858
PIRSF
SMART SM00209
SM00608
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q3TTE6
UniProt Splice Variant
Entrez Gene 11504
UniGene Mm.413379
RefSeq
MGI ID
MGI Symbol Adamts1
OMIM
CCDS
HPRD
IMGT
EMBL AC126936 AK161409
GenPept BAE36379

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca