InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Adamts1

Summary

InnateDB Gene

IDBG-173182.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adamts1

Gene Name

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1

Synonyms

ADAM-TS1; ADAMTS; ADAMTS-1; C3-C5; METH-1; METH1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022893

Encoded Proteins

IDBP-173184

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1

IDBP-539969

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154734:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:85793827-85803113

Strand

Reverse strand

Band

C3.3

Transcripts

ENSMUST00000023610	ENSMUSP00000023610
ENSMUST00000125897	ENSMUSP00000118471
ENSMUST00000138474

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0008270	zinc ion binding

Biological Process

GO:0001542	ovulation from ovarian follicle
GO:0001822	kidney development
GO:0006508	proteolysis
GO:0016525	negative regulation of angiogenesis
GO:0060347	heart trabecula formation

Cellular Component

GO:0005604	basement membrane
GO:0005737	cytoplasm
GO:0031012	extracellular matrix
GO:0031410	cytoplasmic vesicle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000154734

View Gene Order

ENSBTAG00000000706

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_22161

Post-translational protein modification pathway

REACT_118779

Extracellular matrix organization pathway

REACT_118572

Degradation of the extracellular matrix pathway

REACT_200727

O-linked glycosylation pathway

REACT_17015

Metabolism of proteins pathway

REACT_200626

O-glycosylation of TSR domain-containing proteins pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

P97857

TrEMBL

E9PY08 Q3TQF7

UniProt Splice Variant

Entrez Gene

11504

UniGene

Mm.1421 Mm.413379

RefSeq

NM_009621

OMIM

CCDS

CCDS28287

HPRD

IMGT

MGI ID

MGI:109249

MGI Symbol

Adamts1

EMBL

AB001735 AC126936 AK163622 BC040382 BC050834 D67076

GenPept

AAH40382 AAH50834 BAA11088 BAA24501 BAE37426

RNA Seq Atlas

11504