InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TIMP3

Summary

InnateDB Protein

IDBP-5240.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TIMP3

Protein Name

TIMP metallopeptidase inhibitor 3

Synonyms

HSMRK222; K222; K222TA2; SFD;

Species

Homo sapiens

Ensembl Protein

ENSP00000266085

InnateDB Gene

IDBG-5236 (TIMP3)

Protein Structure

UniProt Annotation

Function

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Sorsby fundus dystrophy (SFD) [MIM:136900]: Rare autosomal dominant macular disorder with an age of onset in the fourth decade. It is characterized by loss of central vision from subretinal neovascularization and atrophy of the ocular tissues. Generally, macular disciform degeneration develops in the patients eye within 6 months to 6 years. {ECO:0000269PubMed:7550309, ECO:0000269PubMed:7894485, ECO:0000269PubMed:8634721, ECO:0000269PubMed:8728699, ECO:0000269PubMed:8981947}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	4 [view]
Protein-DNA	3 [view]
Protein-RNA	1 [view]
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008191	metalloendopeptidase inhibitor activity
GO:0046872	metal ion binding

Biological Process

GO:0007601	visual perception
GO:0010951	negative regulation of endopeptidase activity
GO:0051045	negative regulation of membrane protein ectodomain proteolysis
GO:0071310	cellular response to organic substance

Cellular Component

GO:0005604	basement membrane
GO:0005634	nucleus
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001134 Netrin domain
IPR001820 Proteinase inhibitor I35, tissue inhibitor of metalloproteinase
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold

PFAM

PF00965

PRINTS

PIRSF

SMART

SM00206

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P35625