Homo sapiens Gene: TIMP3 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-5236.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | TIMP3 | ||||||||||||||||||
Gene Name | TIMP metallopeptidase inhibitor 3 | ||||||||||||||||||
Synonyms | HSMRK222; K222; K222TA2; SFD | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000100234 | ||||||||||||||||||
Encoded Proteins |
TIMP metallopeptidase inhibitor 3
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008] This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby\'s fundus dystrophy. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 22:32801701-32863043 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | q12.3 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME | |||||||||||||||||||
KEGG | |||||||||||||||||||
INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | P35625 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 7078 | ||||||||||||||||||
UniGene | Hs.644633 Hs.686770 Hs.714083 Hs.714168 | ||||||||||||||||||
RefSeq | NM_000362 | ||||||||||||||||||
HUGO | HGNC:11822 | ||||||||||||||||||
OMIM | 188826 | ||||||||||||||||||
CCDS | CCDS13911 | ||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AK314871 AL023282 BC014277 BT006848 CH471095 CR456593 L15078 S78453 U02571 U14394 U33110 U33111 U33112 U33113 U33114 U38952 U38953 U38954 U38955 U67195 X76227 Z30183 Z98256 | ||||||||||||||||||
GenPept | AAA17672 AAA21815 AAB07547 AAB17602 AAB34532 AAB60373 AAC50393 AAH14277 AAP35494 BAG37386 CAA53813 CAA82918 CAG30479 CAI17996 CAI20115 EAW60038 | ||||||||||||||||||
RNA Seq Atlas | 7078 | ||||||||||||||||||