InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dbnl

Summary

InnateDB Protein

IDBP-261516.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dbnl

Protein Name

drebrin-like

Synonyms

Abp1; mAbp1; SH3P7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105471

InnateDB Gene

IDBG-145110 (Dbnl)

Protein Structure

UniProt Annotation

Function

Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G- actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. {ECO:0000269PubMed:11309416, ECO:0000269PubMed:17476322, ECO:0000269PubMed:18829961, ECO:0000269PubMed:22303001, ECO:0000269PubMed:23223303}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cell cortex. Cytoplasm, cytosol {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell projection {ECO:0000250}. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, podosome. Note=Detected in neuron cell body and cell projections, such as neurites. Colocalizes with cytosolic dynamin in hippocampus neurons (By similarity). Cortical actin cytoskeleton. Associates with lamellipodial actin and membrane ruffles. Colocalizes with actin and cortactin at podosome dots and podosome rosettes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in hippocampus neurons and in the Purkinje cell layer in cerebellum (at protein level). Predominantly expressed in brain, thymus and spleen. Also found in testis, heart and lung. Little or no expression detected in ovary or muscle. {ECO:0000269PubMed:10637315, ECO:0000269PubMed:23223303, ECO:0000269PubMed:9891087}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019904	protein domain specific binding
GO:0051015	actin filament binding

Biological Process

GO:0002376	immune system process
GO:0006897	endocytosis
GO:0007416	synapse assembly
GO:0016601	Rac protein signal transduction
GO:0048812	neuron projection morphogenesis
GO:0071800	podosome assembly

Cellular Component

GO:0000139	Golgi membrane
GO:0001726	ruffle
GO:0002102	podosome
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0014069	postsynaptic density
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0030425	dendrite
GO:0030665	clathrin-coated vesicle membrane