InnateDB Protein
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IDBP-253330.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Tpm1
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Protein Name
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tropomyosin 1, alpha
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Synonyms
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AA986836; AI854628; alpha-TM; TM2; Tm3; Tmpa; Tpm-1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000109315
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InnateDB Gene
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IDBG-180208 (Tpm1)
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Protein Structure
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Function |
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
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Subcellular Localization |
Cytoplasm, cytoskeleton.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Experimentally validated |
Total |
20
[view]
|
Protein-Protein |
20
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
41 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:98809
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InterPro |
IPR000533
Tropomyosin
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PFAM |
PF00261
PF12718
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PRINTS |
PR00194
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P58771
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PhosphoSite |
PhosphoSite-P58771
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TrEMBL |
Q545Y3
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UniProt Splice Variant |
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Entrez Gene |
22003
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UniGene |
Mm.486857
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RefSeq |
NP_001157720
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MGI ID |
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MGI Symbol |
Tpm1
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OMIM |
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CCDS |
CCDS52845
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HPRD |
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IMGT |
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EMBL |
AK002271
AK168640
AK168783
AK169188
CH466522
M22479
X64831
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GenPept |
AAA40483
BAB21978
BAE40499
BAE40617
BAE40964
CAA46043
EDL26151
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