Version 5.4
Mus musculus Gene: Tpm1
Summary
InnateDB Gene IDBG-180208.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tpm1
Gene Name tropomyosin 1, alpha
Synonyms AA986836; AI854628; alpha-TM; TM2; Tm3; Tmpa; Tpm-1
Species Mus musculus
Ensembl Gene ENSMUSG00000032366
Encoded Proteins
IDBP-180210
tropomyosin 1, alpha
IDBP-180212
tropomyosin 1, alpha
IDBP-180214
tropomyosin 1, alpha
IDBP-253308
tropomyosin 1, alpha
IDBP-253310
tropomyosin 1, alpha
IDBP-253312
tropomyosin 1, alpha
IDBP-253314
tropomyosin 1, alpha
IDBP-253316
tropomyosin 1, alpha
IDBP-253318
tropomyosin 1, alpha
IDBP-253320
tropomyosin 1, alpha
IDBP-253322
tropomyosin 1, alpha
IDBP-253324
tropomyosin 1, alpha
IDBP-253326
tropomyosin 1, alpha
IDBP-253328
tropomyosin 1, alpha
IDBP-253330
tropomyosin 1, alpha
IDBP-253332
tropomyosin 1, alpha
IDBP-790535
tropomyosin 1, alpha
IDBP-790536
tropomyosin 1, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140416:
This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:67022590-67049406
Strand Reverse strand
Band C
Transcripts
ENSMUST00000034928 ENSMUSP00000034928
ENSMUST00000030185 ENSMUSP00000030185
ENSMUST00000050905 ENSMUSP00000051888
ENSMUST00000113707 ENSMUSP00000109337
ENSMUST00000113705 ENSMUSP00000109335
ENSMUST00000113701 ENSMUSP00000109331
ENSMUST00000113697 ENSMUSP00000109327
ENSMUST00000113696 ENSMUSP00000109326
ENSMUST00000113695 ENSMUSP00000109325
ENSMUST00000113693 ENSMUSP00000109323
ENSMUST00000113690 ENSMUSP00000109320
ENSMUST00000113689 ENSMUSP00000109319
ENSMUST00000113687 ENSMUSP00000109317
ENSMUST00000113686 ENSMUSP00000109316
ENSMUST00000113685 ENSMUSP00000109315
ENSMUST00000113684 ENSMUSP00000109314
ENSMUST00000129733 ENSMUSP00000138784
ENSMUST00000139046 ENSMUSP00000138514
ENSMUST00000156899
ENSMUST00000129466
ENSMUST00000131279
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 41 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005200 structural constituent of cytoskeleton
GO:0008092 cytoskeletal protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0003065 positive regulation of heart rate by epinephrine
GO:0034614 cellular response to reactive oxygen species
GO:0045214 sarcomere organization
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005862 muscle thin filament tropomyosin
GO:0030016 myofibril
GO:0031941 filamentous actin
GO:0032059 bleb
GO:0032587 ruffle membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000140416
View Gene Order
Pathways
NETPATH
REACTOME
REACT_232053
Striated Muscle Contraction pathway
REACT_235059
Smooth Muscle Contraction pathway
REACT_262759
Muscle contraction pathway
KEGG
mmu04260
Cardiac muscle contraction pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05414
Dilated cardiomyopathy pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20558
Smooth Muscle Contraction pathway
REACT_16969
Striated Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
KEGG
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa04260
Cardiac muscle contraction pathway
hsa05414
Dilated cardiomyopathy pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.121878 Mm.486857
RefSeq NM_001164248 NM_001164249 NM_001164250 NM_001164251 NM_001164252 NM_001164253 NM_001164254 NM_001164255 NM_001164256 NM_024427 XM_006511044 XM_006511049
OMIM
CCDS CCDS23311 CCDS52841 CCDS52842 CCDS52843 CCDS52844 CCDS52845 CCDS52846 CCDS52847 CCDS52848
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca