InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HSP90AA1

Summary

InnateDB Protein

IDBP-20865.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSP90AA1

Protein Name

heat shock protein 90kDa alpha (cytosolic), class A member 1

Synonyms

EL52; HSP86; Hsp89; HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1; HSPCAL4; HSPN; LAP-2; LAP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000216281

InnateDB Gene

IDBG-20861 (HSP90AA1)

Protein Structure

UniProt Annotation

Function

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. {ECO:0000269PubMed:11274138, ECO:0000269PubMed:11276205, ECO:0000269PubMed:15577939, ECO:0000269PubMed:15937123}.

Subcellular Localization

Cytoplasm. Melanosome. Cell membrane. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 879 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	879 [view]
Protein-Protein	877 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0023026	MHC class II protein complex binding
GO:0030235	nitric-oxide synthase regulator activity
GO:0030911	TPR domain binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006200	ATP catabolic process
GO:0006457	protein folding
GO:0006839	mitochondrial transport
GO:0006950	response to stress
GO:0006986	response to unfolded protein
GO:0007165	signal transduction
GO:0007411	axon guidance
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042026	protein refolding
GO:0044281	small molecule metabolic process
GO:0045040	protein import into mitochondrial outer membrane
GO:0045087	innate immune response (InnateDB)
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0046209	nitric oxide metabolic process
GO:0050999	regulation of nitric-oxide synthase activity
GO:0051131	chaperone-mediated protein complex assembly

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome
GO:0071682	endocytic vesicle lumen

Protein Structure and Domains

PDB ID

InterPro

IPR001404 Heat shock protein Hsp90 family
IPR003594 Histidine kinase-like ATPase, C-terminal domain
IPR020568 Ribosomal protein S5 domain 2-type fold
IPR020575 Heat shock protein Hsp90, N-terminal

PFAM

PF00183
PF02518
PF13581

PRINTS

PR00775

PIRSF

PIRSF002583

SMART

SM00387

TIGRFAMs

Post-translational Modifications

Modification

Cross-References