Version 5.4
Homo sapiens Gene: HSP90AA1
Summary
InnateDB Gene IDBG-20861.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSP90AA1
Gene Name heat shock protein 90kDa alpha (cytosolic), class A member 1
Synonyms EL52; HSP86; Hsp89; HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1; HSPCAL4; HSPN; LAP-2; LAP2
Species Homo sapiens
Ensembl Gene ENSG00000080824
Encoded Proteins
IDBP-20863
heat shock protein 90kDa alpha (cytosolic), class A member 1
IDBP-20865
heat shock protein 90kDa alpha (cytosolic), class A member 1
IDBP-592184
heat shock protein 90kDa alpha (cytosolic), class A member 1
IDBP-594808
heat shock protein 90kDa alpha (cytosolic), class A member 1
IDBP-598054
heat shock protein 90kDa alpha (cytosolic), class A member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 17420470
HSP90AA1 (HSP90) positively regulates NOD1 activation.
PMID 18950863
HSP90AA1 regulates the stability of transforming growth factor beta-activated kinase 1 (TAK1) in interleukin-1beta (IL1B)-induced cell signalling and IL1B-induced signalling by interacting with and maintaining the stability of TAK1, suggesting that HSP90AA1 might act as the chaperone of TAK1 in immune and inflammatory responses related with IL1A (IL-1) signal cascades.
Entrez Gene
Summary The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:102080738-102139699
Strand Reverse strand
Band q32.31
Transcripts
ENST00000334701 ENSP00000335153
ENST00000216281 ENSP00000216281
ENST00000554401 ENSP00000451400
ENST00000557089
ENST00000560130
ENST00000553585 ENSP00000450712
ENST00000555662
ENST00000556554
ENST00000557234 ENSP00000452241
ENST00000558600
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 879 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 879 [view]
Protein-Protein 877 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0023026 MHC class II protein complex binding
GO:0030235 nitric-oxide synthase regulator activity
GO:0030911 TPR domain binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0044822 poly(A) RNA binding
GO:0051082 unfolded protein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006200 ATP catabolic process
GO:0006457 protein folding
GO:0006839 mitochondrial transport
GO:0006950 response to stress
GO:0006986 response to unfolded protein
GO:0007165 signal transduction
GO:0007411 axon guidance
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042026 protein refolding
GO:0044281 small molecule metabolic process
GO:0045040 protein import into mitochondrial outer membrane
GO:0045087 innate immune response (InnateDB)
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0046209 nitric oxide metabolic process
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051131 chaperone-mediated protein complex assembly
Cellular Component
GO:0005576 extracellular region
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
GO:0071682 endocytic vesicle lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021270
View Gene Order
ENSBTAG00000006270
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_9
TNFalpha pathway
NetPath_14
IL2 pathway
NetPath_18
IL6 pathway
NetPath_21
RANKL pathway
NetPath_24
TSLP pathway
REACTOME
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_15364
Loss of Nlp from mitotic centrosomes pathway
REACT_15451
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_15296
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_111176
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
REACT_12477
eNOS activation pathway
REACT_115852
Signaling by constitutively active EGFR pathway
REACT_9434
vRNP Assembly pathway
REACT_19236
Sema3A PAK dependent Axon repulsion pathway
REACT_120956
Cellular responses to stress pathway
REACT_111045
Developmental Biology pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_6167
Influenza Infection pathway
REACT_19271
Semaphorin interactions pathway
REACT_12389
eNOS activation and regulation pathway
REACT_163813
Scavenging by Class F Receptors pathway
REACT_12529
Signaling by VEGF pathway
REACT_6802
Innate Immune System pathway
REACT_200624
Attenuation phase pathway
REACT_12508
Metabolism of nitric oxide pathway
REACT_228016
VEGFR2 mediated vascular permeability pathway
REACT_18266
Axon guidance pathway
REACT_6152
Influenza Viral RNA Transcription and Replication pathway
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_111102
Signal Transduction pathway
REACT_115566
Cell Cycle pathway
REACT_6900
Immune System pathway
REACT_228063
EPHA-mediated growth cone collapse pathway
REACT_15479
Centrosome maturation pathway
REACT_200775
HSF1-dependent transactivation pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_2203
G2/M Transition pathway
REACT_200819
Cellular response to heat stress pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_6145
Influenza Life Cycle pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_111217
Metabolism pathway
REACT_200744
HSF1 activation pathway
REACT_116125
Disease pathway
KEGG
hsa04612
Antigen processing and presentation pathway
hsa05215
Prostate cancer pathway
hsa05200
Pathways in cancer pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04621
NOD-like receptor signaling pathway pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
pi3kcipathway
Class I PI3K signaling events
pi3kciaktpathway
Class I PI3K signaling events mediated by Akt
avb3_integrin_pathway
Integrins in angiogenesis
myc_activpathway
Validated targets of C-MYC transcriptional activation
lkb1_pathway
LKB1 signaling events
ilk_pathway
Integrin-linked kinase signaling
reg_gr_pathway
Glucocorticoid receptor regulatory network
hdac_classii_pathway
Signaling events mediated by HDAC Class II
erbb_network_pathway
ErbB receptor signaling network
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
hif1apathway
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
ar_tf_pathway
Regulation of Androgen receptor activity
vegfr1_pathway
VEGFR1 specific signals
il2_pi3kpathway
IL2 signaling events mediated by PI3K
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.525600 Hs.625033 Hs.741646
RefSeq NM_001017963 NM_005348
HUGO
OMIM
CCDS CCDS32160 CCDS9967
HPRD 00777
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca