InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dok2

Summary

InnateDB Protein

IDBP-179483.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dok2

Protein Name

docking protein 2

Synonyms

DokR; Frip;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022698

InnateDB Gene

IDBG-179481 (Dok2)

Protein Structure

UniProt Annotation

Function

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in spleen and lung. {ECO:0000269PubMed:11470823, ECO:0000269PubMed:9478921}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005158	insulin receptor binding