Version 5.4
Mus musculus Gene: Dok2
Summary
InnateDB Gene IDBG-179481.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dok2
Gene Name docking protein 2
Synonyms DokR; Frip
Species Mus musculus
Ensembl Gene ENSMUSG00000022102
Encoded Proteins
IDBP-179483
docking protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147443:
The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:70766036-70778495
Strand Forward strand
Band D2
Transcripts
ENSMUST00000022698 ENSMUSP00000022698
ENSMUST00000171481
ENSMUST00000169599
ENSMUST00000169106
ENSMUST00000171864
ENSMUST00000165654
ENSMUST00000168355
ENSMUST00000164691
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005158 insulin receptor binding
Biological Process
GO:0000165 MAPK cascade
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007265 Ras protein signal transduction
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000147443
View Gene Order
ENSBTAG00000003341
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_211860
Tie2 Signaling pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_11
TCR pathway
NetPath_15
IL3 pathway
NetPath_16
IL4 pathway
NetPath_24
TSLP pathway
REACTOME
REACT_12621
Tie2 Signaling pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_604
Hemostasis pathway
REACT_208597
Cell surface interactions at the vascular wall pathway
REACT_204566
Tie2 Signaling pathway
REACT_212196
Hemostasis pathway
KEGG
INOH
PID NCI
il2_1pathway
IL2-mediated signaling events
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
il4_2pathway
IL4-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.415305
RefSeq NM_010071
OMIM
CCDS CCDS27262
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca