InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dapk2

Summary

InnateDB Protein

IDBP-178936.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dapk2

Protein Name

death-associated protein kinase 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034944

InnateDB Gene

IDBG-178934 (Dapk2)

Protein Structure

UniProt Annotation

Function

Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell deaths signal. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta- catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasmic vesicle, autophagosome lumen {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 is found in the adult brain while isoform 2 is expressed in brains of embryos and young mice (at protein level). {ECO:0000269PubMed:21408167}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding

Biological Process

GO:0006468	protein phosphorylation
GO:0035556	intracellular signal transduction
GO:0042981	regulation of apoptotic process
GO:0043276	anoikis
GO:1900119	positive regulation of execution phase of apoptosis
GO:2001242	regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0031410	cytoplasmic vesicle
GO:0034423	autophagic vacuole lumen

Protein Structure and Domains

PDB ID

MGI:1341297

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt